Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug DevelopmentArticle Published on 2022-11-142022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] binding binding site Chemical chemotypes Comprehensive Consensus COVID19-NMR development drug drug design Drug discovery fragment fragment screening functional identify International Intervention Ligand NMR NMR spectroscopy novel performed predict protease Protein Proteins proteome protocol provide public health RNA genome SARS-CoV-2 SARS-CoV-2. Screening Space the SARS-CoV-2 Vaccines variant variants of concern was used [DOI] 10.1002/anie.202205858 PMC 바로가기
1 H, 13 C and 15 N chemical shift assignment of the stem-loops 5b + c from the 5′-UTR of SARS-CoV-2Article Published on 2022-02-182022-10-27 Journal: Biomolecular Nmr Assignments [Category] COVID-19, [키워드] 5′-UTR 5′-untranslated region 5′-UTR antiviral drug target caused conserved COVID-19 COVID19-NMR elements feature genomic information involved NMR spectroscopy nucleotide pandemic positive Regulation Respiratory disease RNA RNA genome SARS-CoV-2 sequence SL5b SL5b + c SL5c Solution NMR spectroscopy supplementary material Support the Betacoronavirus the SARS-CoV-2 translation viral replication virus [DOI] 10.1007/s12104-021-10053-4 PMC 바로가기 [Article Type] Article
1 H, 13 C and 15 N chemical shift assignment of the stem-loops 5b + c from the 5′-UTR of SARS-CoV-2Article Published on 2022-02-182022-10-27 Journal: Biomolecular Nmr Assignments [Category] Coronavirus, COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] 5′-UTR 5′-untranslated region 5′-UTR antiviral drug target caused conserved COVID-19 COVID19-NMR elements feature genomic information involved NMR spectroscopy nucleotide pandemic positive Regulation Respiratory disease RNA RNA genome SARS-CoV-2 sequence SL5b SL5b + c SL5c Solution NMR spectroscopy supplementary material Support the Betacoronavirus the SARS-CoV-2 translation viral replication virus [DOI] 10.1007/s12104-021-10053-4 PMC 바로가기 [Article Type] Article
1 H, 13 C and 15 N assignment of stem-loop SL1 from the 5′-UTR of SARS-CoV-2Article Published on 2021-08-282022-10-27 Journal: Biomolecular Nmr Assignments [Category] COVID-19, [키워드] 5'-UTR asymmetric base-pair conserved COVID19-NMR function Genome genomic nucleotide produced Replication representing RNA SARS-CoV-2 SARS-CoV-2 RNA single-stranded SL1 Solution NMR spectroscopy Stage subgenomic mRNA supplementary material viral life cycle virus [DOI] 10.1007/s12104-021-10047-2 PMC 바로가기 [Article Type] Article
1 H, 13 C and 15 N assignment of stem-loop SL1 from the 5′-UTR of SARS-CoV-2Article Published on 2021-08-282022-10-27 Journal: Biomolecular Nmr Assignments [Category] Coronavirus, COVID-19, SARS, [키워드] 5'-UTR asymmetric base-pair conserved COVID19-NMR function Genome genomic nucleotide produced Replication representing RNA SARS-CoV-2 SARS-CoV-2 RNA single-stranded SL1 Solution NMR spectroscopy Stage subgenomic mRNA supplementary material viral life cycle virus [DOI] 10.1007/s12104-021-10047-2 PMC 바로가기 [Article Type] Article
Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS‐CoV‐2 GenomeResearch Article Published on 2021-08-032022-10-28 Journal: Angewandte Chemie (International ed. in English) [Category] Coronavirus, SARS, [키워드] assays binding Compound conserved COVID19-NMR defined druggability effective element elements experiments fragment screening functional Genome group in vivo Ligand NMR NMR spectroscopy nuclear nucleotides performed positive Region Regulatory RNA RNA genome RNAs SARS-CoV-2 SARS‐CoV‐2 targets [DOI] 10.1002/anie.202103693 PMC 바로가기 [Article Type] Research Article
1 H, 13 C, 15 N and 31 P chemical shift assignment for stem-loop 4 from the 5′-UTR of SARS-CoV-2Article Published on 2021-04-292022-10-27 Journal: Biomolecular Nmr Assignments [Category] COVID-19, [키워드] 5_SL4 5′-UTR 5′-untranslated region 5′-UTR antiviral agent conserved COVID-19 COVID19-NMR effective Effective vaccines element feature Genome involved Ligand NMR spectroscopy nucleotide Replication required Respiratory disease RNA RNA genome SARS-CoV-2 SARS-CoV-2 virus severe COVID-19 Solution NMR spectroscopy supplementary material target the disease therapeutic intervention translation viral genome viral replication viral RNA genome [DOI] 10.1007/s12104-021-10026-7 PMC 바로가기 [Article Type] Article
1 H, 13 C, 15 N and 31 P chemical shift assignment for stem-loop 4 from the 5′-UTR of SARS-CoV-2Article Published on 2021-04-292022-10-27 Journal: Biomolecular Nmr Assignments [Category] Coronavirus, COVID-19, SARS, [키워드] 5_SL4 5′-UTR 5′-untranslated region 5′-UTR antiviral agent conserved COVID-19 COVID19-NMR effective Effective vaccines element feature Genome involved Ligand NMR spectroscopy nucleotide Replication required Respiratory disease RNA RNA genome SARS-CoV-2 SARS-CoV-2 virus severe COVID-19 Solution NMR spectroscopy supplementary material target the disease therapeutic intervention translation viral genome viral replication viral RNA genome [DOI] 10.1007/s12104-021-10026-7 PMC 바로가기 [Article Type] Article
1H, 13C, and 15N backbone and side chain chemical shift assignments of the SARS-CoV-2 non-structural protein 7Article Published on 2021-04-012023-07-11 Journal: Biomolecular Nmr Assignments [Category] SARS, [키워드] COVID19-NMR non-structural protein SARS-CoV-2 Solution NMR-spectroscopy. [DOI] 10.1007/s12104-020-09985-0 PMC 바로가기
1H,13C and 15N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: “the N-terminal domain-SUD-N”Article Published on 2021-04-012023-07-11 Journal: Biomolecular Nmr Assignments [Category] SARS, [키워드] COVID19-NMR non-structural protein Protein druggability SARS unique domain (SUD) SARS-CoV-2 Solution NMR-spectroscopy. [DOI] 10.1007/s12104-020-09987-y PMC 바로가기